Antagonistic effect of sodium ferulate on glycerol-induced renal oxidative injury in mice.
- Author:
Zhang-xiu LIAO
1
;
Hui WANG
;
Ren-xiu PENG
;
Rui KONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antioxidants; pharmacology; Blood Urea Nitrogen; Coumaric Acids; pharmacology; Creatinine; blood; Glutathione Peroxidase; metabolism; Glycerol; Kidney; metabolism; pathology; Kidney Function Tests; Kidney Tubular Necrosis, Acute; chemically induced; metabolism; pathology; Male; Malondialdehyde; metabolism; Mice; Superoxide Dismutase; metabolism
- From: Acta Pharmaceutica Sinica 2003;38(12):900-903
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the effect of sodium ferulate (SF) on glycerol-induced renal injury.
METHODSGlycerol solution 50% was injected intramuscularly to establish a model of acute tubular necrosis in mice. SF was administered intraperitoneally at the dose of 100-200 mg.kg-1 at the beginning of establishing the model and its effect was observed by monitoring renal function, antioxidative functions and renal pathologic histology.
RESULTSAt 6 and 72 h after glycerol injection, SF treatment (100-200 mg.kg-1) showed significant and dose-dependent antagonistic actions on the increment of blood urea nitrogen (BUN), creatinine (Cr), and N-acetyl-beta-glucosaminidase (NAG) induced by glycerol. The increase of renal malondialdehyde (MDA) content and the decrease of glutathione content, glutathione peroxidase (GSH-Px), glutathione S-transferase (GST), catalase (Cat) and superoxide dismutase (SOD) activities resulting from glycerol injection were remarkably inversed by SF at the dose of 200 mg.kg-1. Meanwhile, improvement of the renal histology was observed as well.
CONCLUSIONSF showed beneficial effect on glycerol-induced acute tubular necrosis due to its antioxidative action.
