Effects of conjugated linoleic acid on obese MSG mice with insulin resistance.
- Author:
Su-juan SUN
1
;
Zhu-fang SHEN
;
Yue-teng CHEN
;
Ling TANG
;
Shi-ying DING
;
Ming-zhi XIE
Author Information
- Publication Type:Journal Article
- MeSH: Adipose Tissue; metabolism; Animals; Animals, Newborn; Blood Glucose; metabolism; Body Weight; drug effects; Female; Glucose Tolerance Test; Insulin; blood; Insulin Resistance; Linoleic Acids, Conjugated; pharmacology; Male; Mice; Mice, Inbred ICR; Obesity; chemically induced; metabolism; Sodium Glutamate; Tumor Necrosis Factor-alpha; metabolism
- From: Acta Pharmaceutica Sinica 2003;38(12):904-907
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the effect of conjugated linoleic acid (CLA) on obese MSG mice with insulin resistance.
METHODSAbout four months old, obese MSG mice with insulin resistance were divided into control, CLA and rosiglitazone groups and drugs were administrated ig once a day. Body weights were recorded regularly, insulin and glucose tolerance were tested. In addition, serum insulin and TNF-alpha concentrations in serum and fat tissues were determined.
RESULTSCLA was shown to reduce the body weight and fat weight in MSG mice, but can not improve the abnormal insulin and glucose tolerance in these mice. Indeed, the serum insulin and TNF-alpha concentrations in the fat tissues of the group treated with CLA were higher than those in the models and the insulin sensitivity index was significantly lower than that in the model mice.
CONCLUSIONCLA can reduce the body weight of MSG mice, but can not improve the insulin resistance in these mice.
