Unitary-core osmotic pump tablet for controlled release of water-insoluble drug.
- Author:
Long-xiao LIU
1
;
Qing XU
;
Gilson KHANG
;
John-moon RHEE
;
Hai-bang LEE
Author Information
- Publication Type:Journal Article
- MeSH: Calcium Channel Blockers; administration & dosage; chemistry; Delayed-Action Preparations; Drug Delivery Systems; Nifedipine; administration & dosage; chemistry; Osmosis; Polyethylene Glycols; pharmacology; Potassium Chloride; pharmacology; Solubility; Tablets; Technology, Pharmaceutical; methods
- From: Acta Pharmaceutica Sinica 2003;38(12):966-967
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study unitary-core osmotic pump tablet for delivering water-insoluble drug for 24 hours.
METHODSUnitary-core osmotic pump tablet was prepared using nifedipine as the model drug. The effects of various core formulation variables on drug release were studied.
RESULTSPolyethylene oxide and potassium chloride have comparable positive effects on drug release, whereas, nifedipine has markedly negative effect on drug release.
CONCLUSIONUnitary-core osmotic pump tablet is very easy in preparation and it can deliver water-insoluble drug in substantially constant rate for 24 hours.
