Synthesis and antioxidative activity of 2-substituted phenyl-5-(3'-indolyl)-oxazole derivatives.
- Author:
Yu-ping MIAO
1
;
Ren WEN
;
Hitoshi AOSHIMA
;
Pei-gen ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Antioxidants; chemical synthesis; chemistry; Indoles; chemistry; isolation & purification; Molecular Structure; Oxazoles; chemistry; isolation & purification
- From: Acta Pharmaceutica Sinica 2004;39(1):37-40
- CountryChina
- Language:English
-
Abstract:
AIMTo study the synthesis of 5-(3'-indolyl)-oxazoles and their antioxidative activity.
METHODSThe amides were prepared from tryptophan and different acid derivatives by the catalytic dehydration of dicyclohexyl carbodiimide (DCC). The characteristic heterocyclic ring system of 5-(3'-indolyl)-oxazoles was constructed by oxidative cyclization of amide, using dicholorodicyanoquinone (DDQ). Their antioxidative activity in vitro was tested using DPPH system.
RESULTSEleven 2-substituted phenyl-5-(3'-indolyl)-oxazoles were prepared, the compounds 21 and 22 have shown antioxidative activity 3-4 times stronger than that of Vit E, and the compound 29 showed antioxidative activity almost as same as Vit E.
CONCLUSIONThree 5-(3'-indoyl)-oxazole compounds synthesized showed potent antioxidative effect and they would be a good antioxidants.
