Comparison of genetic polymorphism of cytochrome CYP2C19 between men and women in Chinese population.
- Author:
Liang-qing FU
1
;
Feng HUANG
;
De-zheng WU
;
Jun-hua GUO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aryl Hydrocarbon Hydroxylases; genetics; Asian Continental Ancestry Group; China; Cytochrome P-450 CYP2C19; Female; Gene Frequency; Genotype; Humans; Male; Middle Aged; Mixed Function Oxygenases; genetics; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Sex Factors
- From: Acta Pharmaceutica Sinica 2004;39(3):161-163
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo assess the effect of gender on genetic polymorphism of cytochrome CYP2C19 in Chinese population.
METHODSThe genetic polymorphism of 140 healthy Chinese were analysed by PCR-RFLP (restriction fragment length polymorphism).
RESULTSOf 52 genotyped male subjects, 23 (44.23%) were homozygous for wildtype (wt/wt), 6 (11.54%) were homozygous for CYP2C19 m1 (m1/m1), and 23 (44.23%) were heterozygous for CYP2C19 m1 or CYP2C19 m2 (wt/m1 or wt/m2); and among the 88 genotyped female subjects, 31 (35.23%) were homozygous for wildtype (wt/wt), 13 (14.82%) were homozygous for CYP2C19 m1 (m1/m1), and 44 (50.0%) were heterozygous for CYP2C19 m1 or CYP2C19 m2 (wt/m1 or wt/m2); no homozygous genotype for CYP2C19 m2 (m2/m2) was found in the study.
CONCLUSIONThere is no statistical difference in ocurance of wt/wt and m1/m1 between in male and in female, so gender have no significant effect on genetic polymorphism of cytochrome CYP2C19.
