Synthesis and anti-inflammatory analgesic activities of sinomenine derivatives.
- Author:
Xian-rong YE
1
;
Ke-xu YAN
;
Ke-mei WU
;
Xiao-zhang FENG
;
Yu-ming HUANG
;
Ping QIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Inflammatory Agents, Non-Steroidal; chemical synthesis; pharmacology; Edema; pathology; Mice; Molecular Conformation; Molecular Structure; Morphinans; chemical synthesis; isolation & purification; pharmacology; Pain Measurement; Plants, Medicinal; chemistry; Rats; Sinomenium; chemistry
- From: Acta Pharmaceutica Sinica 2004;39(3):180-183
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo provide basic data for the synthesis of new sinomenine derivatives.
METHODSThe C ring in sinomenine was modified.
RESULTSSeven compounds were prepared and screened for anti-inflammatory and analgesic activities. Compounds 2 and 5 showed better activities.
CONCLUSIONModification of the C ring in sinomenine should be worthy to be studied further.
