Study on distribution of safflor yellow A in tissues of mice.
- Author:
Yue-qing LIU
1
;
Hai-tao ZHOU
;
Kai-shun BI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Carthamus tinctorius; chemistry; Chalcone; analogs & derivatives; blood; isolation & purification; pharmacokinetics; Chromatography, High Pressure Liquid; Female; Flowers; chemistry; Male; Mice; Plants, Medicinal; chemistry; Quinones; blood; isolation & purification; pharmacokinetics; Tissue Distribution
- From: Acta Pharmaceutica Sinica 2004;39(3):217-219
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the distributive character of safflor yellow A in mice.
METHODSA RP-HPLC method for the determination of safflor yellow A in tissues was established and applied to determine safflor yellow A in biological samples.
RESULTSAfter iv injection of Safflor yellow A in mice, the AUC of safflor yellow A was hightest in plasma, followed by kidney, liver, lung, heart, spleen. But it was not found in the brain.
CONCLUSIONThe distribution of safflor yellow A in the body is abroad and the speed of its process is swift.
