Preparation of all-trans retinoic acid mixed micelles injection.
- Author:
Lin ZHU
1
;
Jia-bi ZHU
;
Ying TU
;
Xu TIAN
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Agents; administration & dosage; chemistry; Bile Acids and Salts; Drug Stability; Micelles; Phosphatidylcholines; Solubility; Technology, Pharmaceutical; methods; Tretinoin; administration & dosage; chemistry
- From: Acta Pharmaceutica Sinica 2004;39(3):220-222
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo increase the solubility and bioavailability of all-trans retinoic acid (ATRA).
METHODSUsing the principle of lecthin/bile salt mixed micelle to prepared ATRA injection. The best formulation was obtained by the turbidity and three-phase figure.
RESULTSATRA mixed micelles injection is stable. The average size of the mixed micelle is 17.8 nm, poly. index 0.495, zeta potential -16.5 mV.
CONCLUSIONThe method can be used to prepare the stable injection.
