Synthesis of 1-indole substituted beta-carboline alkaloid and its derivatives and evaluation of their preliminary antitumor activities.
- Author:
Xiao-chun DONG
1
;
Ren WEN
;
Jian-bin ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Alkaloids; chemical synthesis; chemistry; pharmacology; Animals; Antineoplastic Agents; chemical synthesis; chemistry; pharmacology; Carbolines; chemical synthesis; chemistry; pharmacology; Cell Division; drug effects; Cell Line, Tumor; Indoles; Leukemia P388; pathology; Mice; Molecular Structure; Tryptamines
- From: Acta Pharmaceutica Sinica 2004;39(4):259-262
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo synthesize eudistomin U and its 6-OCH3/Br derivatives and 5'-Br derivatives as antitumor agents.
METHODSUsing tryptamine and indole-3-aldehyde as starting materials, through condensation, Pictet-Spengler cyclization and dehydrogenation three steps, the alkaloids and its derivatives were prepared.
RESULTSThe structures of the compounds were determined by 1HNMR, MS and HRMS. Antitumor activity in vitro was tested.
CONCLUSIONEudistomin U and its derivatives were synthesized. The results showed that they all showed antitumor activities against mouse P388 strain.
