Pleiotropic effects of herbs characterized with blood-activating and stasis-resolving functions on angiogenesis.
10.1007/s11655-015-2405-x
- Author:
Li TAO
1
;
Sheng WANG
1
;
Yang ZHAO
1
;
Ai-Yun WANG
1
;
Lei ZHANG
2
;
Jun-Shan RUAN
3
;
Fang-Tian FAN
4
;
Yu-Ping LIU
1
;
Yao LI
1
;
Zhi-Qiang YUE
1
;
Wen-Hui QIAN
5
;
Wen-Xing CHEN
1
;
Yin LU
6
Author Information
1. Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
2. Department of Pharmacy, Provincial Hospital Affiliated to Anhui Medical University, Hefei, 230001, China.
3. Fujian Provincial Hospital, Clinical College of Fujian Medical University, Fuzhou, 350001, China.
4. Department of Pharmacology, Hanlin College, Nanjing University of Chinese Medicine, Taizhou Jiangsu Province, 225300, China.
5. Department of Pharmaceutics, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002, China.
6. Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China. profyinlu@163.com.
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
anti-angiogenesis;
arteriogenesis;
blood activating and stasis resolving;
pathological angiogenesis;
physiological angiogenesis;
pro-angiogenesis
- MeSH:
Angiogenesis Inhibitors;
chemistry;
therapeutic use;
Animals;
Antineoplastic Agents;
therapeutic use;
Drugs, Chinese Herbal;
chemistry;
therapeutic use;
Humans;
Models, Biological;
Neovascularization, Pathologic;
blood;
drug therapy
- From:
Chinese journal of integrative medicine
2016;22(10):795-800
- CountryChina
- Language:English
-
Abstract:
Accumulative evidences have underpinned the nature candidates from Chinese medicine (CM), particularly CM served as blood activating and stasis resolving (BASR, Huoxue Huayu in Chinese) by targeting tumor-associated angiogenesis. However, recent experiment research on the therapeutic angiogenesis by BASR-CM attracts wide attention and discussion. This opinion review focused on the underlying link between two indications and anticipated that (1) BASR-CM might emphasize on a balanced multi-cytokines network interaction; (2) BASR-CM might address on the nature of diseases prior to differently affecting physiological and pathological angiogenesis; (3) BASR-CM might mainly act on perivascular cells, either promotes arteriogenesis by increasing arteriogenic factors in ischemic diseases, or simultaneously keep a quiescent vasculature to impede angiogenesis in tumor context.
