Changes in small intestinal motility and related hormones by acupuncture stimulation at Zusanli (ST 36) in mice.
- Author:
Jung-Hee JANG
1
;
Deuk-Joo LEE
1
;
Chang-Hwan BAE
1
;
Ki-Tae HA
1
;
Sunoh KWON
2
;
Hi-Joon PARK
2
;
Dae-Hyun HAHM
2
;
Hyejung LEE
2
;
Seungtae KIM
3
Author Information
- Publication Type:Journal Article
- Keywords: acupuncture; gastrin; gastrointestinal motility; ghrelin; motilin; vasoactive intestinal peptide
- MeSH: Acupuncture Points; Acupuncture Therapy; Animals; Gastrointestinal Motility; physiology; Hormones; blood; Intestine, Small; physiology; Male; Mice, Inbred C57BL
- From: Chinese journal of integrative medicine 2017;23(3):215-220
- CountryChina
- Language:English
-
Abstract:
OBJECTIVESTo clarify the effects of acupuncture stimulation at Zusanli (ST 36) on the hormonal changes.
METHODSEight-week-old male C57BL/6 mice received acupuncture stimulation at acupoint ST 36 or Quchi (LI 11) once a day for 3 or 5 days in the acupuncture-stimulated groups, but not received in the normal group (n=6 in each group). On day 3 or 5, animals were given 0.1 mL of charcoal orally with a bulbed steel needle, 30 min after the last acupuncture stimulation. Ten minutes later, mice were anesthetized, and the intestinal transit and the concentrations of vasoactive intestinal peptide (VIP), motilin, ghrelin and gastrin in the serum were measured.
RESULTSCompared to no acupuncture stimulation, acupuncture stimulation at ST 36 for 5 days increased the intestinal transit and down-regulated the concentration of VIP and up-regulated the concentrations of motilin, ghrelin and gastrin (P<0.05 or 0.01), whereas acupuncture stimulation at LI 11 did not change them signifificantly (P>0.05).
CONCLUSIONAcupuncture stimulation at ST 36 for 5 days enhances the small intestinal motility and regulates the secretion of hormones related to small intestinal motility.
