Negative correlation of Nogo-A with the malignancy of oligodendroglial tumor.
- Author:
Nan-Xiang XIONG
1
;
Hong-Yang ZHAO
;
Fang-Cheng ZHANG
;
Zhu-Qiang HE
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Biomarkers, Tumor; analysis; metabolism; Brain Neoplasms; diagnosis; metabolism; physiopathology; Down-Regulation; physiology; Female; Humans; Immunohistochemistry; Male; Middle Aged; Mitotic Index; Myelin Proteins; analysis; metabolism; Neoplasm Invasiveness; diagnosis; Nogo Proteins; Oligodendroglioma; diagnosis; metabolism; physiopathology; Predictive Value of Tests
- From: Neuroscience Bulletin 2007;23(1):41-45
- CountryChina
- Language:English
-
Abstract:
OBJECTIVENogo-A is an axon regeneration inhibitor, and its function in central nervous system (CNS) is still unknown. The present study is to explore the relationship between the expression of Nogo-A and the malignancy of oligodendroglial tumors in patients.
METHODSTumor tissue samples with different malignancy grade were obtained from the hospitals. The samples used for detection had been diagnosed as oligodendroglial tumors (oligodendroglioma or anaplastic oligodendroglioma). The expression of Nogo-A was detected by immunohistochemistry and western-blot analysis. The correlation test between the Nogo-A expression and the morphological changes (the percentages of atypical cells and mitotic cells in the tumors) related to the malignancy of tumor tissues was performed.
RESULTSThere was significant negative correlation between the Nogo-A expression and the morphological change of tumor tissues according to immunohistochemistry. Western-blot analysis also indicated that the gray value of Nogo-A protein band in the oligodendroglioma group was significantly higher than that in the anaplastic oligodendroglioma group.
CONCLUSIONNogo-A expression was negatively correlated with the malignancy grade of oligodendroglial tumors.
