Epigenetics and neural stem cell commitment.
- Author:
Hai-Liang TANG
1
,
2
;
Jian-Hong ZHU
Author Information
1. Department of Neurosurgery, Fudan University, Huashan Hospital
2. National Key Laboratory for Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Differentiation;
Chromatin Assembly and Disassembly;
DNA Methylation;
Epigenesis, Genetic;
Genomic Imprinting;
Humans;
Neurons;
physiology;
Stem Cells;
physiology
- From:Neuroscience Bulletin
2007;23(4):241-248
- CountryChina
- Language:English
-
Abstract:
Neural stem cell is presently the research hotspot in neuroscience. Recent progress indicates that epigenetic modulation is closely related to the self-renewal and differentiation of neural stem cell. Epigenetics refer to the study of mitotical/meiotical heritage changes in gene function that cannot be explained by changes in the DNA sequence. Major epigenetic mechanisms include DNA methylation, histone modification, chromatin remodeling, genomic imprinting, and non-coding RNA. In this review, we focus on the new insights into the epigenetic mechanism for neural stem cells fate.
