Mitochondrial dysfunction and Huntington disease.

Author: Wei-Yan ZHANG ^{1
,

2
,

3} ; E-mail: ZHQIN5@HOTMAIL.COM. ; Zhen-Lun GU ; Zhong-Qin LIANG ; Zheng-Hong QIN
Author Information

1. SooChow University School of Life Sciences
2. Department of Pharmacology, Soochow University School of Medicine, Suzhou 215123, China
3. E-mail: zhqin5@hotmail.com.
Publication Type:Journal Article
From: Neuroscience Bulletin 2006;22(2):129-136
CountryChina
Language:English
Abstract: Huntington disease (HD) is a chronic autosomal-dominant neurodegenerative disease. The gene coding Huntingtin has been identified, but the pathogenic mechanisms of the disease are still not fully understood. This paper reviews the involvement of mitochondrial dysfunction in pathogenesis of HD.