Regulatory genes controlling neural stem cells differentiation into neurons.
- Author:
Li ZHANG
1
,
2
;
E-mail: ZHQIN5@HOTMAIL.COM.
;
Zhen-Lun GU
;
Zheng-Hong QIN
Author Information
1. Department of Pharmacology, Soochow University School of Medicine, Suzhou 215123, China
2. E-mail: zhqin5@hotmail.com.
- Publication Type:Journal Article
- From:
Neuroscience Bulletin
2006;22(5):294-300
- CountryChina
- Language:English
-
Abstract:
The recent progress in neural stem cells (NSCs) research has shed lights on possibility of repair and restoration of neuronal function in neurodegenerative diseases using stem cells. Induction of stem cells differentiate into mature neurons is critical to achieve the clinical applications of NSCs. At present, molecular mechanisms modulating NSC differentiation are not fully understood. Differentiation of stem cells into neuronal and glial cells involves an array of changes in expression of transcription factors. Transcription factors then trigger the expression of a variety of central nervous system (CNS) genes that lead NSCs to differentiate towards different cell types. In this paper, we summarized the recent findings on the gene regulation of NSCs differentiation into neuronal cells.
