First experience with intracytoplasmic sperm injection for extreme oligozoospermia associated with Crohn's disease and 6-mercaptopurine chemotherapy.
- Author:
E Scott SILLS
1
;
Michael J TUCKER
Author Information
- Publication Type:Case Reports
- MeSH: Adult; Crohn Disease; complications; drug therapy; Female; Humans; Immunosuppressive Agents; administration & dosage; Male; Mercaptopurine; administration & dosage; Oligospermia; complications; therapy; Pregnancy; Pregnancy Outcome; Sperm Injections, Intracytoplasmic
- From: Asian Journal of Andrology 2003;5(1):76-78
- CountryChina
- Language:English
-
Abstract:
AIMTo describe the reproductive outcome following intracytoplasmic sperm injection (ICSI) for male factor infertility associated with Crohn's disease and 6-mercaptopurine (6-MP) chemotherapy.
METHODSThe male partner of a couple suffered from severe Crohn's disease and received a 3-month course of 6-MP for this condition. Two spontaneous conceptions were established before 6-MP, although post-chemotherapy semen analysis found the sperm concentration to be 8,000/mL. In vitro fertilization (IVF) with ICSI and embryo transfer was performed.
RESULTSThe woman underwent an uncomplicated controlled ovarian hyperstimulation sequence using a combined rec-FSH+hMG protocol, following late luteal phase pituitary downregulation. This culminated in the retrieval of 18 oocytes, 11 of which were fertilized with ICSI. She later delivered a normal male infant without urogenital anomaly. Four nontransferred blastocysts were cryopreserved.
CONCLUSIONThis report describes the first successful birth after ICSI for severe oligozoospermia associated with Crohn's disease and 6-MP therapy. We outline salient features of Crohn's disease, 6-MP pharmacology, and their relevance to human fertility.
