Absence of sperm meiotic segregation error of chromosomes 1, 9, 12, 13, 16, 18, 21, X and Y in a case of 100% necrozoospermia.
- Author:
Ashutosh HALDER
1
;
Vandana CHADDHA
;
Savita AGARWAL
;
Ashish FAUZDAR
Author Information
1. Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. ashutoshhalder@yahoo.co.in
- Publication Type:Case Reports
- MeSH:
Adult;
Aneuploidy;
Chromosome Mapping;
Chromosome Segregation;
genetics;
Humans;
In Situ Hybridization, Fluorescence;
Male;
Meiosis;
Necrosis;
Oligospermia;
genetics;
pathology;
Spermatozoa;
pathology
- From:
Asian Journal of Andrology
2003;5(2):163-166
- CountryChina
- Language:English
-
Abstract:
Varying degrees of necrozoospermia are common findings in cases of male sub-fertility; however, it is rare to find persistent and 100 % necrozoospermia. A case of persistent 100 % necrozoospermia was presented in this paper, where aneuploidy analysis was carried out on sperm. No known associations like thyrotoxicosis, genital infection, spinal injury and diabetes were found. Sperm fluorescent in situ hybridization (FISH) was carried out to evaluate sperm aneuploidy for chromosome 1, 9, 12, 13, 16, 18, 21, X and Y and did not show any excess of aneuploidy over controls. To the best of our knowledge, this is the first attempt on meiotic segregation analysis on 100 % necrozoospermic patients.
