Research progress on the effect of glucocorticoid receptor signaling pathways in bladder cancer.
- Author:
Sheng FENG
1
,
2
;
Jijun CHEN
3
;
Yichun ZHENG
4
Author Information
1. Department of Urology, the First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou 310006, China
2. Department of Urology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
3. Department of Urology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
4. Department of Urology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. zhengyichun@yeah.net.
- Publication Type:Journal Article
- MeSH:
Animals;
Antineoplastic Agents;
pharmacology;
Cell Nucleus;
genetics;
Humans;
Prognosis;
Protein Transport;
genetics;
Receptors, Glucocorticoid;
agonists;
physiology;
Signal Transduction;
genetics;
Transcriptional Activation;
drug effects;
physiology;
Urinary Bladder Neoplasms;
genetics;
physiopathology
- From:
Journal of Zhejiang University. Medical sciences
2016;45(6):655-660
- CountryChina
- Language:Chinese
-
Abstract:
Glucocorticoid receptor (GR) is identified as a member of nuclear receptor family. To exert its biological action, the ligand bound GR is translocated from the cytoplasm into the nucleus by regulating transcriptional signals of related genes. In clinical practice, the effects of glucocorticoid are often mediated by GR signaling pathways. An increasing number of studies have indicated that GR signaling pathways play an essential role in the proliferation, invasion and prognosis of bladder cancer. Meanwhile, the new-generation selective GR activator improves its anti-tumor effects, and at the same time reduces the adverse reactions of hormones, which probably raises the prospect for the treatment of bladder cancer.
