Localization of gestational age reference table and its application in prenatal screening.
- Author:
Linlin DOU
1
;
Guohui YANG
1
;
Weiming MO
1
Author Information
1. Prenatal Screening Center, Zhejiang Xiaoshan Hospital, Hangzhou 311201, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Body Weights and Measures;
standards;
Cephalometry;
standards;
statistics & numerical data;
Chorionic Gonadotropin, beta Subunit, Human;
blood;
standards;
Chromosomes, Human, Pair 18;
Down Syndrome;
diagnosis;
embryology;
Epidemiologic Measurements;
Female;
Fetal Development;
Gestational Age;
Head;
embryology;
Humans;
Mass Screening;
methods;
standards;
statistics & numerical data;
Menstrual Cycle;
Neural Tube Defects;
diagnosis;
embryology;
Pregnancy;
Prenatal Diagnosis;
methods;
standards;
statistics & numerical data;
Reference Values;
Trisomy;
diagnosis;
Trisomy 18 Syndrome;
alpha-Fetoproteins;
analysis;
standards
- From:
Journal of Zhejiang University. Medical sciences
2017;46(1):59-65
- CountryChina
- Language:Chinese
-
Abstract:
To establish a fetal biparietal diameter (BPD)-gestational age formula based on the data of pregnant women from Xiaoshan District of Hangzhou, and to evaluate its application in prenatal screening.Data of 3500 pregnant women with gestational age between 15 weeks and 19 weeks+6 receiving prenatal screening in Xiaoshan Hospital during May 2014 and May 2015 were collected. BPDs were used to establish a localized BPD-gestational age formula. The localized formula was used to evaluate the prenatal screening risks in 1759 pregnant women with irregular menstrual cycles or uncertain last menstrual period (LMP) in Xiaoshan District, and the results were compared with those calculated using formula in LifeCycle 4.0.With localized formula, the total positive rate of Down syndrome, trisomy 18 syndrome and deformity of neural tube was decreased from 6.96% to 5.85% (<0.05), in which the positive rate of Down syndrome decreased (<0.05), that of deformity of neural tube increased (<0.05), and that of trisomy 18 syndrome remained the same (>0.05). The median MoMs of free-hCG β and α-fetoprotein calculated using localized formula were significantly different from those calculated using the formula in LifeCycle 4.0 (all<0.05), and the former ones were more closer to 1. For women of fetus diagnosed with the above diseases, the positive rate calculated using localized formula was almost the same as that calculated using the formula in LifeCycle 4.0.BPD-gestational age formula should be localized based on the statistical analysis of the local population, which will help to reduce the false positive rate, and make the results more accurate and reliable in prenatal screening.
