Research progress on the animal models and treatment strategies of diabetic foot ulcer.
- Author:
Siqian GAO
1
;
Yongmei SHEN
2
;
Funeng GENG
2
;
Yanhua LI
3
;
Jianqing GAO
4
;
Author Information
1. Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
2. Sichuan Gooddoctor Pharmaceutical Group Co., Ltd., Chengdu 610000, China.
3. Jiangsu Engineering Research Center for New-Type External and Transdermal Preparations, Changzhou 213000, China.
4. Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
- Publication Type:Journal Article
- MeSH:
Animals;
Anti-Inflammatory Agents;
therapeutic use;
Diabetic Foot;
etiology;
genetics;
therapy;
Disease Models, Animal;
Humans;
Matrix Metalloproteinase Inhibitors;
therapeutic use;
Matrix Metalloproteinases;
genetics;
metabolism;
Mice;
Neovascularization, Physiologic;
physiology
- From:
Journal of Zhejiang University. Medical sciences
2017;46(1):97-105
- CountryChina
- Language:Chinese
-
Abstract:
The suitable experimental animal model is important in research of pathogenesis and therapeutic strategies of diabetic foot ulcer, and the murine model is the most commonly used one at present. It can be divided into two types: the animal model simulating pathological conditions and the model simulating clinical symptoms. This article reviews the current research progress on the mechanisms of diabetic ulcer pathogenesis, and relevant treatment strategies, including the inhibition of matrix metalloproteinases (MMPs) expression, promotion of angiogenesis and anti-inflammatory therapy.
