Advances in nanoparticle-targeting tumor associated macrophages for cancer imaging and therapy.
- Author:
Guo FENGLIANG
1
;
Tang GUPING
2
;
H U QINGLIAN
1
Author Information
1. College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.
2. Institute of Organic and Medicinal Chemistry, Zhejiang University, Hangzhou 310028, China. tangguping@zju.edu.cn.
- Publication Type:Journal Article
- From:
Journal of Zhejiang University. Medical sciences
2017;46(2):167-172
- CountryChina
- Language:Chinese
-
Abstract:
Tumor tissues are composed of tumor cells and complicate microenvironment. Tumor associated macrophages (TAMs) as an important component in tumor microenvironment, play fundamental roles in tumor progression, metastasis and microenvironment regulation. Recently, studies have found that nanotechnology, as an emerging platform, provides unique potential for cancer imaging and therapy. With the nanotechnology, TAMs imaging presents direct evidence for cancer development, progression, and the effectiveness of cancer treatments; it also can regulate the immunosuppression of tumor microenvironment and improve therapeutic efficiency through TAMs targeted killing or phenotypic transformation. In this article, we illustrate the function of TAMs and review the latest development in nano-carriers and their applications in tumor associated macrophage targeting cancer imaging and therapy.
