Research progress on genes mutations related to sulfa drug resistance in.
- Author:
Mengyan WANG
1
;
Biao ZHU
2
Author Information
1. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infection Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
2. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infection Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. zhubiao1327@zju.edu.cn.
- Publication Type:Journal Article
- From:
Journal of Zhejiang University. Medical sciences
2017;46(5):563-569
- CountryChina
- Language:Chinese
-
Abstract:
pneumonia is an opportunistic infection among immunocompromised people. Studies have found that the increased resistance to sulfa drugs ofmay be associated with the mutation of dihydropteroate synthase () gene and dihydrofolate reductase () genes, but the mechanism is still unclear. The mutation ofandgenes may be the result of sulfa drugs selection or spontaneous genetic polymorphism, and it can be acquired from person-to-person transmission. This article reviews the cause, molecular epidemiology ofandgene mutation, and the relationship betweenandgene mutation and clinical outcomes.
