Preliminary study of new imaging agent, 99mTc-Rituximab, for sentinel lymph node biopsy of primary breast cancer.
- Author:
Jin-feng LI
1
;
Tao OUYANG
;
Xue-juan WANG
;
Tian-feng WANG
;
Yun-tao XIE
;
Zhao-qing FAN
;
Bao-he LIN
;
Zhi YANG
;
Ben-yao LIN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Breast Neoplasms; pathology; Female; Humans; Lymph Nodes; pathology; Lymphatic Metastasis; Middle Aged; Rituximab; Sensitivity and Specificity; Sentinel Lymph Node Biopsy; methods; Technetium
- From: Chinese Journal of Surgery 2006;44(9):600-602
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the feasibility and effects of new imaging agent, 99mTc-Rituximab, for sentinel lymph nodes biopsy (SLNB) of primary breast cancer.
METHODSSLNB were performed in eighty-five primary breast cancer patients using 99mTc-Rituximab combined with patent blue. Metastases in sentinel lymph nodes were detected with routine pathologic and immunohistochemistry method.
RESULTSThe successful rate of SLNB using combining method of 99mTc-Rituximab and patent blue was 96% (82/85). Thirty cases of SLN (37%, 30/82) were metastasis positive, including twenty-four positive cases by HE staining and six by immunohistochemistry method. SLN was the only metastasis lymph nodes in 18/30 cases. One case has false negative SLN metastasis. The sensitivity and accuracy of SLNB were 97% (30/31) and 99% (81/82). The specificity was 100% (51/51). The false negative rate was 3% (1/30) and the negative predictive value was 98% (51/52). The positive predictive value was 100% (31/31). Internal mammary sentinel lymph node lymphoscintigraphy was positive in eleven cases but all of them were confirmed metastases negative by pathologic examination.
CONCLUSIONS99mTc-Rituximab, as a new imaging agent, can keep SLN imaging durable and can make SLNB more convenient. Through primary clinical manifestation, higher sensitivity and accuracy could obtained by combining method of 99mTc-Rituximab and patent blue for SLNB of primary breast cancer.