Comparison of melatonin receptor mRNA expression in bilateral paravertebral muscles in adolescent idiopathic scoliosis.
- Author:
Yong QIU
1
;
Liang WU
;
Bin WANG
;
Yang YU
;
Ze-zhang ZHU
;
Bang-ping QIAN
;
Wei-wei MA
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Case-Control Studies; Child; Female; Humans; Male; Muscle, Skeletal; metabolism; RNA, Messenger; genetics; Receptors, Melatonin; biosynthesis; genetics; Scoliosis; metabolism
- From: Chinese Journal of Surgery 2006;44(12):826-829
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the change of melatonin receptor mRNA expression in paravertebral muscles in adolescent idiopathic scoliosis (AIS), and analyze its relationship with the etiology of AIS.
METHODSTwenty cases with average age of (15.1 +/- 2.2) years and average Cobb angle of 56 degrees +/- 16 degrees , including 10 cases with Cobb angle > 50 degrees and 10 cases with Cobb angle
RESULTSThe MT2 mRNA expression of paravertebral muscles on concave side was higher than that on convex side in AIS and CS groups (P < 0.05), but the MT1 mRNA expression showed no significant difference (P > 0.05). In AIS group, the ratio of MT2 mRNA expression on concave side compared with convex side in cases with Cobb angle > 50 degrees and cases with Cobb angle
CONCLUSIONSThe melatonin receptor expression in bilateral paravertebral muscles in AIS is asymmetric, which may be a secondary change and has no important role in the pathogenesis of AIS.
