The relationship between expression of interleukin-8 and prognosis of breast cancer.
- Author:
Chen YAO
1
;
Shen-ming WANG
;
Dan XIE
;
Hui-xi WU
;
Dong-ying CHEN
;
Ying LIN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Breast Neoplasms; diagnosis; metabolism; pathology; Female; Humans; Immunohistochemistry; Interleukin-8; biosynthesis; Lymphatic Metastasis; Middle Aged; Prognosis; Receptor, ErbB-2; biosynthesis; Receptors, Estrogen; biosynthesis; Receptors, Progesterone; biosynthesis
- From: Chinese Journal of Surgery 2006;44(13):900-903
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of interleukin-8 (IL-8) and its prognostic significance in breast cancer.
METHODSExpression of IL-8 in 113 breast cancers, 19 breast benign tumors and 20 breast normal tissues was examined by tissue microarray using immunohistochemistry, and the association of IL-8 expression with patient's clinico-pathological characteristics and prognosis was further analyzed.
RESULTSThe positive rate of IL-8 expression in breast cancer was 27.4%, which was significantly higher than that in benign tumor and normal tissue of breast (P = 0.002). IL-8 expression related to histological type (P = 0.040) and lymph node status (P = 0.021). The expression of IL-8 was observed to correlate negatively with ER and PR status (P = 0.015 and P = 0.034), and correlate positively with C-erbB-2 status (P = 0.002). In addition, Kaplan-Meier curves of disease-free survival analysis showed a significant difference between IL-8 positive groups and negative group (P = 0.031).
CONCLUSIONSIL-8 might be a poor prognostic factor for human breast cancer, and also might be a novel molecular marker to predicate the occurrence and progression of breast cancer.
