Clinical analysis in diagnosis and treatment of 11 patients with hereditary renal cell carcinoma.
- Author:
Da-xin GONG
1
;
Xia WANG
;
Ze-liang LI
;
Yuan-jun JIANG
;
Zhi-xi SUN
;
Chui-ze KONG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Renal Cell; diagnosis; genetics; surgery; Female; Humans; Kidney Neoplasms; diagnosis; genetics; surgery; Male; Middle Aged; Retrospective Studies
- From: Chinese Journal of Surgery 2006;44(14):963-965
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the diagnosis and treatment of hereditary renal cell carcinoma.
METHODSClinical data of 11 patients with hereditary renal cell carcinoma were analyzed retrospectively. Eight patients were male and 3 were female, age ranged from 32 to 67 (mean: age 48 years). Four cases were bilateral renal cell carcinoma, and 4 were multiple renal cell carcinoma. Two cases were diagnosed as Von Hippel-Lindau syndrome, 6 as familial clear cell renal cell cancer, and 3 as hereditary papillary renal carcinoma.
RESULTSTen patients performed nephron-sparing surgery and/or radical nephrectomy and 1 had no operation. The patients were followed up from 12 to 114 months. Tumor recurrence was observed in 4 patients, 1 patient died of tumor metastasis, and 2 died of other causes. Four patients survived free of tumor.
CONCLUSIONSHereditary renal carcinoma appears in the youth, and it is predominantly multiple and bilateral. Nephron-sparing surgery is the standard method of treatment for the patients.
