The Influence of Iron Deficiency on Helicobacter pylori Eradication.
10.7704/kjhugr.2016.16.2.82
- Author:
Sung Eun KIM
1
;
Moo In PARK
;
Seun Ja PARK
;
Won MOON
;
Jae Hyun KIM
;
Kyoungwon JUNG
;
Kwang Il SEO
;
Seong Kyeong LIM
;
Jin Kyu JUNG
;
Hyeon Jin KIM
;
Go Eun YEO
;
Sung Chan JEON
;
Duk Song CHO
;
You Jin HAN
Author Information
1. Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea. mipark@kosinmed.or.kr
- Publication Type:Original Article
- Keywords:
Helicobacter pylori;
Disease eradication;
Iron
- MeSH:
Adenocarcinoma;
Breath Tests;
Disease Eradication;
Ferritins;
Gastric Mucosa;
Helicobacter pylori*;
Helicobacter*;
Humans;
Iron*;
Male;
Retrospective Studies;
Risk Factors;
Urease;
Virulence
- From:The Korean Journal of Helicobacter and Upper Gastrointestinal Research
2016;16(2):82-87
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Helicobacter pylori is a distinctive pathogen that lives in the gastric mucosa and is a well known risk factor of gastric adenocarcinoma. Iron deficiency aggravates the development of H. pylori-induced premalignant and malignant lesions in a cagA-dependent manner, enhancing H. pylori virulence. The aim of this study was to identify the relationship between iron deficiency and H. pylori eradication rates. MATERIALS AND METHODS: Participants who received 7 days of first-line triple therapy with serum iron level measured in parallel were retrospectively investigated between 2005 and 2014. H. pylori eradication was confirmed by the rapid urease test or 13C-urea breath test at least 4 weeks after completion of triple therapy. Iron deficiency was defined as either a serum iron level less than 50 µg/dL or a serum ferritin level less than 12 ng/mL. RESULTS: A total of 194 patients received 7 days of first-line triple therapy along with parallel serum iron level measurements over the 10-year period. The mean average age was 53.3 years (range, 21~86 years), and 135 patients (69.6%) were male. The overall H. pylori eradication rate was 83.5%. Proportions of eradication success with ferritin level less than 12 ng/mL and iron less than 50 µg/dL were 90.5% and 88.6%, respectively. However, there was no statistical difference in eradication rates according to iron deficiency. CONCLUSIONS: Iron deficiency might not be related with H. pylori eradication rates in this study. Further large-scale studies are needed to confirm this result.
