Expressions of IL-13 and IL-13Rα2 in eosinophilic chronic rhinosinusitis with nasal polyps and clinical implications
10.3760/cma.j.issn.1673-0860.2015.03.011
- VernacularTitle:嗜酸粒细胞性慢性鼻-鼻窦炎白细胞介素13及其受体α2的表达与意义
- Author:
Yan ZHENG
1
;
Pengfei LIU
;
Lijuan GUO
;
Entong WANG
Author Information
1. 空军总医院耳鼻咽喉头颈外科
- Keywords:
Sinusitis;
Nasal polyp;
Eosinophils;
Interleukin-13;
Receptors,interleukin-13
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2015;50(3):230-235
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expressions of interleukin (IL) 13 and its receptor IL-13Rα2 in eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) and non-ECRSwNP and their clinicopathological implications.Methods A total of 60 consecutive patients with CRSwNP who underwent endoscopic sinus surgery (ESS) were divided into two groups of ECRSwNP (n =27) and non-ECRSwNP (n =33) based on tissue eosinophil count (more than five cells per high power field) with postoperative pathological examination.Before ESS,the severities of symptoms,nasal polyps,and sinonasal diseases on CT were scored,peripheral blood eosinophil count and percentage,and total serum IgE level were measured.IL-13 and IL-13Rα2 expressions in polyp tissues were examined with immunohistochemistry.SPSS 16.0software was used to analyze the data.Results There was no significant differences between ECRSwNP and non-ECRSwNP groups in the mean symptom scores (t =0.102,P ＞ 0.05),but ECRSwNP,compared to nonECRSwNP,demonstrated a higher incidence of bilateral polyps (x2 =15.879,P ＜ 0.01),a higher mean score of nasal polyps (3.6 ± 1.1 vs 2.1 ± 0.8,t =4.009,P ＜ 0.01) or diseases on CT (t =4.428,P ＜0.01).And also a significant difference existed between two groups in mean blood eosinophil count (t =3.148,P ＜ 0.01) or percentage (t =3.038,P ＜ 0.01),but no significant difference in total serum levels of IgE (t =0.659,P ＞ 0.05).There was a closed correlation between tissue eosinophil count and blood eosinophil count (r =0.683,P ＜0.01) or percentage (r =0.631,P ＜0.01) in ECRSwNP,but not in nonECRSwNP.The expressions of both IL-13 and IL-13Rα2 increased significantly in ECRSwNP compared to non-ECRSwNP (scores 8.1 ± 1.6 vs.5.4 ± 1.6; 8.8 ± 1.4 vs.4.8 ± 1.6,t value was 4.749,8.010,P＜ 0.01).Conclusions IL-13 and IL-13Rα2 are associated closely with pathogenesis of ECRSwNP.Subtyping CRSwNP and studying underly mechanism can be helpful to make treatment strategy for CRSwNP.
