The relationship between human papillomavirus and prognosis of oropharyngeal squamous cell carcinoma: a meta analysis
10.3760/cma.j.issn.1673-0860.2015.03.012
- VernacularTitle:人乳头状瘤病毒与口咽鳞状细胞癌预后相关性的meta分析
- Author:
Yuanyuan XU
1
;
Suling HONG
;
Quan ZENG
;
Shixun ZHONG
;
Yucheng YANG
;
Houyong KANG
;
Guohua HU
Author Information
1. 400016,重庆医科大学附属第一医院耳鼻咽喉科
- Keywords:
Oropharyngeal neoplasms;
Carcinoma,squamous cell;
Papillomaviridae;
Prognosis;
Meta-analysis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2015;50(3):236-243
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine survival differences in prognosis and survival between patients with HPV-positive and those with HPV-negative oropharyngeal squamous cell carcinoma (OPSCC).Methods Pubmed,Embase,Web of science and Medline databases were searched from their inception till June 2014.A random-effect meta-analysis was used to pool study estimates evaluating overall (all-cause mortality),disease-specific (death from OPSCC),disease-free (recurrence free),progression-free survival outcomes and local regional control rate in HPV-positive vs HPV-negative OPSCC.After study selection,two reviewers assessed and extracted data independently.Meta-analysis was performed using the STATA 11.0software.Results Thirty-seven studies were included.HPV-positive OPSCC patients had a better overall survival compared to HPV-negative patients (HR 0.39,95％ CI 0.32-0.46).HPV-positive OPSCC patients had a significantly lower disease specific mortality (HR 0.31,95％ CI 0.22-0.39) and were less likely to experience progression or recurrence of their cancers than HPV-negative patients (HR 0.34,95％CI 0.25-0.42).Both disease-free survival and progression-free survival were significantly improved in patients with HPV-positive OPSCC (HR 0.38,95％ CI 0.29-0.47 and HR 0.46,95％ CI 0.29-0.63,respectively).Conclusions HPV infection is an important prognostic factor of OPSCC.Stratified therapies can be applied in OPSCC based on HPV status of tumours.
