Research advances in hereditary epilepsy and precision drug therapy.
- Author:
Ge LYU
1
;
Yun-Li HAN
Author Information
1. Department of Pediatrics, First Affiliated Hospital of Guangxi Medical University, Nanning 530000, China. 756293195@qq.com.
- Publication Type:Journal Article
- MeSH:
Epilepsy;
drug therapy;
etiology;
genetics;
High-Throughput Nucleotide Sequencing;
Humans;
Ion Channels;
genetics;
Precision Medicine
- From:
Chinese Journal of Contemporary Pediatrics
2017;19(10):1118-1123
- CountryChina
- Language:Chinese
-
Abstract:
Epilepsy is a common nervous system disease. It has been found that the pathogenesis of epilepsy is associated mutations in various genes, including genes encoding voltage-dependent ion channel, genes encoding ligand-gated ion channel, and solute carrier family genes. Different types of epilepsy caused by different mutations have different responses to drugs, and therefore, diagnosis and medication guidance based on genes are new thoughts for developing therapies. With the application of next-generation sequencing technology, more and more genes will be determined, which helps to further study the pathogenic mechanism of mutant genes and provides a basis for precision drug therapy for epilepsy.
