Clinical analysis of 15 851 children at risk of inherited metabolic diseases.
- Author:
Shu-Xiang LIN
1
;
Jian-Bo SHU
;
Chao WANG
;
Rui PAN
;
Ying-Tao MENG
;
Chun-Hua ZHANG
;
Bi-Li ZHANG
;
Dan WANG
;
Yu-Qin ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Acidosis; etiology; Adolescent; Amino Acid Metabolism, Inborn Errors; complications; diagnosis; Child; Child, Preschool; Developmental Disabilities; etiology; Female; Gas Chromatography-Mass Spectrometry; Humans; Infant; Infant, Newborn; Male; Metabolism, Inborn Errors; complications; diagnosis; Retrospective Studies; Risk
- From: Chinese Journal of Contemporary Pediatrics 2017;19(12):1243-1247
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the value of urine gas chromatography-mass spectrometry (GC-MS) in the screening of children at risk of inherited metabolic diseases (IMD), and to identify the disease spectrum of IMD and the clinical characteristics of children with IMD.
METHODSThe clinical data of 15 851 children at risk of IMD who underwent urine GC-MS in the Tianjin Children's Hospital between February 2012 and December 2016 were retrospectively analyzed.
RESULTSIn the 15 851 children, 5 793 (36.55%) were detected to have metabolic disorders. A total of 117 (0.74%) children were confirmed to have IMD, including 77 cases of methylmalonic acidemia (65.8%). The clinical manifestations of confirmed cases in the neonatal period mainly included jaundice, metabolic acidosis, abnormal muscular tension, feeding difficulty, poor response, and lethargy or coma. The clinical manifestations of confirmed cases in the non-neonatal period mainly included delayed mental and motor development, metabolic acidosis, convulsion, recurrent vomiting, and anemia.
CONCLUSIONSGC-MS is an effective method for the screening for IMD in children at risk. Methylmalonic acidemia is the most common IMD. The clinical manifestations of IMD are different between the confirmed cases in the neonatal and non-neonatal periods.
