Research advances in the association between transient receptor potential cation channel 6 and kidney disease.
- Author:
Shan CAO
1
;
Yun-Guang LIU
Author Information
1. Graduate School of Youjiang University for Nationalities, Baise, Gangxi 533000, China. 454785063@qq.com.
- Publication Type:Journal Article
- From:
Chinese Journal of Contemporary Pediatrics
2018;20(1):72-76
- CountryChina
- Language:Chinese
-
Abstract:
Transient receptor potential cation channel 6 (TRPC6) is a member of the transient receptor superfamily encoded by the TRPC6 gene and is widely expressed in tissues and organs of the human body, especially in the glomerular podocytes. TRPC6 interacts with various slit diaphragm (SD) proteins including podocin, nephrin, ACTN4, and CD2AP to maintain the normal structure and function of glomerular podocytes. Foot process fusion caused by podocyte damage due to various factors is the most important morphological change in kidney disease. This article reviews the biological function of TRPC6 and its effect on kidney disease.
