Animal experimental study of the treatment of periapical disease with recombinant human bone morphogenetic protein-2 composite.
- Author:
Huo-guang PENG
1
;
Zhu-ping WANG
;
Ting-yan LIU
;
Duo WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Collagen; Dogs; Humans; Periapical Diseases; Recombinant Proteins; Root Canal Filling Materials; Transforming Growth Factor beta
- From: West China Journal of Stomatology 2005;23(3):204-207
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of the treatment of periapical diseases with recombinant human netic protein (rhBMP-2) composite in dog models so as to provide basis for its clinical application.
METHODSThe endotoxin-bacteria mixed fluid was injected into each root canal of the experimental teeth of dogs and the animal periapical were built. The rhBMP-2 composite was mixed by rhBMP-2, TCP, collagen and metronidazole and used in the treatment cal diseases in dog models as root apex screen. The imageology and pathology research were went on.
RESULTSThe effective rate of the experimental group was remarkably higher than that of the carrier group and the control group with remarkable ference (P < 0.05). The quality of the repair of tissue was obviously better than the two other groups.
CONCLUSIONThe rhBMP-2 composite is a promising biological root-canal filling material.
