Effects of orthodontic force on tumor necrosis factor alpha protein expression in the inflammatory periodontal tissues.

Author: Li-wen XIAO ¹ ; Yang-xi CHEN ; Ding BAI ; Jing-ju ZHANG ; Pei-jia DUAN
Author Information

1. Dental Department, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Publication Type:Journal Article
MeSH: Adult; Animals; Humans; Molar; Periodontitis; Rats; Stress, Mechanical; Tumor Necrosis Factor-alpha
From: West China Journal of Stomatology 2005;23(3):208-210
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo explore the combined effects of orthodontic force and inflammation on the remodelling of periodontal tissues.
METHODSThe upper first molars underwent mesial orthodontic force on 48 rats suffering experimental periodontitis and 48 rats injected lipopolysaccharide, respectively.
RESULTSThe TNF-alpha protein expression in the compressed periodontal tissues fluctuated during 0, 2, 12 hours and 2, 7, 14 days stages, the OD value got to the peak in the compressed periodontal tissues in 2 days.
CONCLUSIONThe mechanical remodelling effects were hindered due to the circumstance of acute or chronic inflammation. The research suggests that the orthodontic treatment to adult patients with periodontal inflammation should be taken carefully.