Influence of the expression of heat shock protein 70 in maxillofacial squamous cell carcinoma by thermochemotherapy.
- Author:
Sheng-zhi WANG
1
;
Li WANG
;
Xiang-dong GAO
;
Zhou CHENG
;
Hong-guang BI
;
Da-zhang WANG
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Squamous Cell; HSP70 Heat-Shock Proteins; Humans
- From: West China Journal of Stomatology 2005;23(4):277-279
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the influence of thermochemotheraphy on the expression of HSP70 in maxillofacial squamous cell carcinoma.
METHODS12 patients were treated with thermochemotheraphy twice a week, altogether 10 times. After 8 mg of Pingyangmycin infused, the patients were treated with microwave hyperthermia at 43 degrees C for 40 min. The part of carcinoma tissue was removed with surgical operations at before treatment and aftre five times of treatment. The expression of HSP70 in tumor cells was determined by SP immunohistochemcial method.
RESULTSThe expression of HSP70 in tumor cells was enhanced obviously by thermochemotherapy.
CONCLUSIONSpecial high expression of HSP70 in the tumor cells was induced by thermochemotherapy. With the antigen presenting action and other action, HSP70 have special antitumor effect.
