Relationship between the expression of cyclooxygenase-2 and microvessel density in oral squamnous cell carcinoma.
- Author:
Xuan-ping CAO
1
;
Song-tao ZHANG
;
Hao-yang WU
;
Xue-jun LIU
;
Yuan-yuan ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Carcinoma, Squamous Cell; Cyclooxygenase 2; Female; Humans; Immunohistochemistry; Lymphatic Metastasis; Male; Microvessels; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Neovascularization, Pathologic
- From: West China Journal of Stomatology 2005;23(5):431-433
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detective the relationship between cyclooxygenase-2 (COX-2) and angiogenesis in oral squamous cell carcinoma (OSCC) and its clinical significance through observing the expression of COX-2 and determining microvessel density (MVD) in OSCC.
METHODSPV-9000 immunohistochemistry was used to determine the expression of COX-2 and CD34, which was used to determine MVD, in 76 OSCC tissues and 12 normal oral mucosa tissues.
RESULTSOverexpression of COX-2 was detected in OSCC, and was more intense compared with normal epithelium (P < 0.001). The high expression of COX-2 in OSCC was related to neck lymphnode metastasis, tumor size, TNM stage and histological grade (P <0.05). The MVD value in COX-2-positive group was much higher than that in COX-2-negative group (P < 0.01) and that in normal oral mucosa tissues (P < 0.01).
CONCLUSIONThe high expression of COX-2 in OSCC was significantly associated with MVD, neck lymphnode metastasis, tumor size, TNM stage and histological grade. COX-2 might be one of the important factors in the angiogenesis of OSCC.
