Association of estrogen receptor gene polymorphisms and primary trigeminal neuralgia.
- Author:
Cui-jiao HUANG
1
;
Hu WANG
;
Ming-yue WU
;
Jing-ju ZHANG
;
Qing-rong MENG
;
Chun-hua FU
;
Jian-zhong DENG
;
Ping YI
Author Information
- Publication Type:Journal Article
- MeSH: Female; Genotype; Humans; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Receptors, Estrogen; Trigeminal Neuralgia
- From: West China Journal of Stomatology 2005;23(6):495-497
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of estrogen receptor (ER) gene polymorphism and primary trigeminal neuralgia.
METHODSBy polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), ER gene polymorphism was analyzed in 20 trigeminal neuralgia (TR) patients and 20 control individuals, and the distribution of ER genotype was compared in TR group and control group.
RESULTSThere was no significant difference in frequencies of allele and genotype in XbaI or PvuII polymorphism or XbaI with PvuII polymorphisms together between TR group and control group (P > 0.05). The genotypic distribution of Xx or PpXx in TR group was higher than control group, and it was contary to xx, ppxx or Ppxx in TR group and control group.
CONCLUSIONXbaI or PvuII polymorphism may be related to TR. Women with PpXx genotype may be a dangerous factor to primary trigeminal neuralgia.
