The Analysis of Post Operative Treatment of Malignant Melanoma Using High Dose Interferon-alpha2b Immunotherapy: Preliminary Report.
10.5292/jkbjts.2012.18.2.78
- Author:
So Hak CHUNG
1
;
Hyun Ik JO
Author Information
1. Department of Orthopedic Surgery, Kosin University Gospel Hospital, Busan, Korea. chowanda@naver.com
- Publication Type:Original Article
- Keywords:
malignant melanoma;
alpha2b;
immunotherapy
- MeSH:
Body Surface Area;
Disease-Free Survival;
Electrons;
Follow-Up Studies;
Humans;
Immunotherapy;
Interferon-alpha;
Melanoma;
Neoplasm Metastasis;
Recurrence;
Thorax;
Tomography, Emission-Computed
- From:The Journal of the Korean Bone and Joint Tumor Society
2012;18(2):78-82
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Interferon-alpha2b using immunotherapy of malignant melanoma is known to increase the microscopic enemies that remain after surgical resection of the tumor to prevent recurrence, disease-free survival and overall survival. Authors in patients with malignant melanoma after surgical resection and high-dose interferon-alpha immunotherapy treated group of disease-free survival and overall survival compared with the results of the treatment of immune therapy to a preliminary report. MATERIALS AND METHODS: From February 2010 to October 2012 at our institution between being diagnosed with malignant melanoma after surgical immunotherapy treated patients were analyzed. Patients was evaluated using the stage AJCC stage IIA 3 cases, IIB 1 cases, IV 1 were as follows. Follow-up period of at least 7 months, and a maximum of 32 months. As maintenance therapy after the first induction therapy group underwent immunotherapy interferon-alpha of body-surface area per 200,000 IU five times in a week for 4 weeks sedentary and body surface area a total of 48 weeks per week to 100,000 IU three times subcutaneously. These patients for local recurrence and metastases, and distant metastasis were investigated disease-free survival was investigated. RESULTS: Interferon-evaluation through follow-up chest computed tomography (CT) and positron emission computed tomography (PET CT) in patients who underwent the alpha immunotherapy results above both local recurrence and metastases without evidence of distant metastases. CONCLUSION: The high-dose alpha2b immunotherapy performed in patients to prevent the local recurrence of the tumor and metastasis to the current or future ultimate survival and disease-free survival improvement achieved is additional study and follow-up will be needed.
