Study on preparation of matrine double-sensitive colon-specific pellets and in vitro release.
- Author:
Yong-Gang ZHANG
;
Jing JIE
- Publication Type:Journal Article
- MeSH: Acrylic Resins; chemistry; Administration, Oral; Alkaloids; administration & dosage; chemistry; pharmacokinetics; Chitosan; chemistry; Chlorides; chemistry; Colon; metabolism; Delayed-Action Preparations; administration & dosage; chemistry; pharmacokinetics; Drug Compounding; methods; Drug Delivery Systems; methods; Ferric Compounds; chemistry; Humans; Hydrogen-Ion Concentration; Mannans; chemistry; Quinolizines; administration & dosage; chemistry; pharmacokinetics; Reproducibility of Results; Tablets, Enteric-Coated; Time Factors
- From: China Journal of Chinese Materia Medica 2014;39(9):1603-1606
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare matrine double-sensitive colon-specific pellets and study the factors affecting its quality and evaluateing the colon-specific effects of preparation.
METHODMatrine enzyme-sensitive pellets core were prepared by carboxymethyl konjac glucomannan as the main carrier material, and coated the core by acrylic resin II and III to prepare matrine double-sensitive colon-specific pellets. The prescription and technology of the matrine colon-specific pellets were studied by the single factor investigation, through the in vitro release test and coating rate determination.
RESULTThe optimized process conditions: FeCl3 concentration is 4.0 g x L(-1), chitosan concentration is 3.0 g x L(-1), carboxymethyl konjac glucomannan concentration is 20 g x L(-1), mixed gel solution pH value is 3. The release of matrine is less than 30% in the simulation of the upper gastrointestinal medium. The release of matrine is close to 100% in simulated full gastrointestinal medium, the coating weight is 7%.
CONCLUSIONThe prepared pellets have good colon positioning effect in vitro.