Effects of micronization on micromeritics properties of baicalin.
- Author:
Hong-Mei YAN
;
Dong-Mei DING
;
E SUN
;
Jing WANG
;
Xiao-Bin JIA
;
Zhen-Hai ZHANG
- Publication Type:Journal Article
- MeSH:
Calorimetry, Differential Scanning;
Drugs, Chinese Herbal;
chemistry;
Flavonoids;
chemistry;
Particle Size;
Solubility;
Wettability;
X-Ray Diffraction
- From:
China Journal of Chinese Materia Medica
2014;39(4):653-656
- CountryChina
- Language:Chinese
-
Abstract:
Baicalin extremely fine powder was made by using ball-mill and the effect of micronization on the micromeritics properties of baicalin was studied and analyzed. The microstructures of baicalin ordinary and extremely fine powder were compared by scanning electron microscope, differential scanning calorimeter and X-ray diffraction and the powder characteristic of them was investigated. The hygroscopicity was studied. The effect of micronization on the dissolution of baicalin was investigated. The results showed that the chemical constituents of baicalin were not changed after micronization with better compressibility. It was confirmed that micronization technology had a certain application value in promoting the insoluble component of baicalin absorption with higher dissolution.
