Research about effect of spray drying conditions on hygroscopicity of spray dry powder of gubi compound's water extract and its mechanism.
- Author:
Jie ZONG
;
Qi SHAO
;
Hong-Qing ZHANG
;
Yong-Lan PAN
;
Hua-Xu ZHU
;
Li-Wei GUO
- Publication Type:Journal Article
- MeSH: Desiccation; methods; Drugs, Chinese Herbal; chemistry; Hydrophobic and Hydrophilic Interactions; Particle Size; Powders; chemistry; Temperature; Water; analysis; Wettability
- From: China Journal of Chinese Materia Medica 2014;39(4):663-668
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate moisture content and hygroscopicity of spray dry powder of Gubi compound's water extract obtained at different spray drying conditions and laying a foundation for spray drying process of Chinese herbal compound preparation.
METHODIn the paper, on the basis of single-factor experiments, the author choose inlet temperature, liquid density, feed rate, air flow rate as investigated factors.
RESULTThe experimental absorption rate-time curve and scanning electron microscopy results showed that under different spray drying conditions the spray-dried powders have different morphology and different adsorption process.
CONCLUSIONAt different spray-dried conditions, the morphology and water content of the powder is different, these differences lead to differences in the adsorption process, at the appropriate inlet temperature and feed rate with a higher sample density and lower air flow rate, in the experimental system the optimum conditions is inlet temperature of 150 degrees C, feed density of 1.05 g x mL(-1), feed rate of 20 mL x min(-1) air flow rate of 30 m3 x h(-1).