Synthesis and characterization of 9-O-alkyl substituted palmatine derivatives.
- Author:
Zi-Ming LV
;
Shao-Hua ZHAO
;
Jun-Qing LIANG
;
Peng-Fei TU
- Publication Type:Journal Article
- MeSH:
Berberine Alkaloids;
chemical synthesis;
chemistry;
Drugs, Chinese Herbal;
chemical synthesis;
chemistry;
Molecular Structure
- From:
China Journal of Chinese Materia Medica
2014;39(4):699-703
- CountryChina
- Language:Chinese
-
Abstract:
For the establishment of chemical library of protoberberines provided for the bio-activity screening, the target compounds were synthesized by thermal degradation and nucleophilic substitution reactions with the bio-active alkaloid, palmatine (1), as the raw material, and their structures were identified and conformed by 1H-NMR and MS spectra. Among them, 13 compounds were new.
