Effect of zige lyophilized powder for injection in improving acute cerebral microcirculation disturbance in rats.
- Author:
Yuan-Hong SHANG
;
Hong-Jin WANG
;
Jin-Feng TIAN
;
Cong-Cong ZHANG
;
Xiao-Na ZHANG
;
Xiao-Yu XU
- Publication Type:Journal Article
- MeSH: Animals; Brain; blood supply; drug effects; Brain Ischemia; drug therapy; physiopathology; Cerebrovascular Circulation; drug effects; Drugs, Chinese Herbal; administration & dosage; Humans; Male; Powders; administration & dosage; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2014;39(4):733-737
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of Zige lyophilized powder for injection in improving the acute cerebral microcirculation disturbance in rats.
METHODWindow craniotomy was performed for rats after the drug administration for 14 days. The experimental microcirculation disturbance model was duplicated with high molecule dextran. After the drug administration, the micro-vein diameters of cerebral pla mater of various groups were observed and recorded under the biological microscope. The blood flow volume was monitored by laser Doppler flow-meter. HCT was measured by the electric resistance method. The hemorheological indexes were detected by the auto-hemorheological instrument.
RESULTZige lyophilized powder for injection (16.40, 32.70, 65.40 mg x kg(-1)) could significantly expand the micro-vein diameter of cerebral pla mater, improve the downward trend of the blood flow volume, and reduce the various hemorheological indexes.
CONCLUSIONZige lyophilized powder for injection shows the effect in improving the cerebral microcirculation.