Albumin kinetics in patients with severe sepsis.
- Author:
Wei-qin LI
1
;
Xin-ying WANG
;
Hong ZHU
;
Heng-shan TAN
;
Jian-zhong RUI
;
Yang BAO
;
Zhu-fu QUAN
;
Ning LI
;
Jie-shou LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Sepsis; metabolism; Serum Albumin; metabolism
- From: Chinese Journal of Surgery 2003;41(6):423-426
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the mechanism of hypoalbuminemia in patients with severe sepsis.
METHODSI(125)-labeled albumin was administered intravenously to 10 health volunteers and 10 patients with severe sepsis. Blood samples were taken at 0, 1, 2, 4, 8, 12, 24 hours and 2, 3, 4, 5, 6, 7, 9, 11, 13, 15, 18, 22, 25 days for the measurement of the dose of gamma-radiation and the curve of concentration and time. Then the half-life time (t(1/2)), apparent volume of distribution (V(d)) and transportation rate (K(12)) from center compartment to side compartment of albumin were calculated.
RESULTSThe half-life time in septic group was obviously shorter than that in control group (8.2 +/- 1.4 vs. 12.5 +/- 1.7, P < 0.01). The transportation rate in the septic group was higher than that in the control group [(4.4 +/- 1.9) x 10(-2)/h vs. (2.4 +/- 0.6) x 10(-2)/h, P < 0.05]. There was no significant difference in apparent volume of distribution between the two groups.
CONCLUSIONSIn patients with severe sepsis, the distribution rate of albumin from vessel to tissue was obviously increased and the decomposition rate of albumin was markedly improved.
