Effects on neuronal ultrastructure and nervous system of monkey after selective cerebral profound hypothermia and blood flow occlusion.
- Author:
Wei XU
1
;
Ji-yao JIANG
;
Peng-fan YANG
;
Yong-jun GAO
;
Shao-long FANG
;
Deng-li FU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain Ischemia; etiology; pathology; physiopathology; prevention & control; Cerebrovascular Circulation; Disease Models, Animal; Extracorporeal Circulation; adverse effects; Female; Haplorhini; Hypothermia, Induced; Male; Time Factors
- From: Chinese Journal of Surgery 2004;42(8):486-488
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of deep hypothermia on the neuronal ultrastructure and nervous system of monkey after selective cerebral profound hypothermia and blood flow occlusion.
METHODSBrain-local extracorporeal circulation was established by right internal carotid artery deep hypothermic perfusion and homolateral external jugular vein backflow, brain blood flow was recovered from circulatory arrest 60 - 80 minutes late and monkey came back naturally.
RESULTSIn all 7 monkeys, 5 were succeeded in being build up the models except for 2 because of technic problems, and 4 of them lived up for ever. The function of nervous system grade, essential organ and neuronal ultrastructure were normal.
CONCLUSIONSelective cerebral profound hypothermia can increase the ability of brain to endure hypovolemia and hypoxidosis and prolong the time of blood flow occlusion.
