The clinical application on composite graft of acellular allo-dermal matrix and auto-microskin on escharectomy after deep burns.
- Author:
Yun-chuan PAN
1
;
Jia-qin XU
;
Yan-kun CHEN
;
Song-ling LI
;
Si-huan CHEN
;
Duo-neng WU
;
De-bin ZENG
;
Zun-hong LIANG
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Burns; surgery; Female; Humans; Male; Middle Aged; Skin Transplantation; methods; Tissue Donors; Transplantation, Autologous; Transplantation, Homologous; Treatment Outcome
- From: Chinese Journal of Surgery 2004;42(7):410-412
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo present the clinical application of composite graft of acellular allo-dermis matrix (ADM) with thin auto-microskin on burn wound.
METHODS8 inpatients with 18 full thickness skin burn wounds were transplanted with allo-ADM after eschar was excised, then the auto-microskin and allo-human skin were covered on the area of the matrix, the wound where no allo-ADM grafting were covered as control groups only with auto-microskin and allo-human skin. The area of donor to wound is 1:5 - 1:8.
RESULTSSurvived rate of 18 pieces composite skin that allo-ADM with auto-microskin were grafted were 94%. After following up for 3 to 13 months, the skins of complex grifting had well elastic and smooth texture compared to auto-microskin grafted, they appeared less cicatrisation and ulceration. 3 months after operation, it was indicated by histological examination that tightknit the epithelial-dermal conjunction and epidermal papilla structure could be identified in the allo-ADM skin and there were orderly collagenous fibres, but scar skin structure was observed in that auto-microskin grifted area.
CONCLUSIONThe graft effectiveness of allo-ADM and auto-microskin was better than that of auto-microskin, and this method could be used on major deep burn wound healing.
