Study on relationship of fucosyltransferase gene types in breast cancer with metastasis and prognosis.
- Author:
Ke-feng DING
1
;
Shu ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Breast Neoplasms; enzymology; genetics; pathology; Female; Fucosyltransferases; genetics; Genotype; Humans; Middle Aged; Polymerase Chain Reaction; Prognosis
- From: Chinese Journal of Surgery 2004;42(9):546-550
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of five types of fucosyltransferase gene (Fuc-T), the important biosynthesis gene of sialylated carbohydrate antigens (Sialyl Lewis A, Sialyl Lewis X), with metastasis and prognosis of breast cancer.
METHODSThe real-time quantitative PCR of five-type Fuc-T III, IV, V, VI, VII genes was performed in 80 patients with breast cancer.
RESULTSThe result showed that Fuc-TVII gene had higher gene copy compared to other type of Fuc-T in breast cancer. The grading of Fuc-TVII gene was related to lymph node metastasis and poor disease-free survival. Statistically difference was significant (P < 0.01). Fuc-T III, IV, V, VI gene were not significant relation to the metastasis and prognosis in 80 cases.
CONCLUSIONSThese findings suggest that Fuc-TVII gene is a prognostic indicator of breast cancer, and it may be play an important role in the biosynthesis of sialylated carbohydrate antigens in breast cancer.
