The growth inhibition effect of alpha-adrenoceptor antagonists on androgen- independent prostate cancer cell line.
- Author:
Shi-jun LIU
1
;
Ke-xin XU
;
Xiao-feng WANG
;
Shu-kun HOU
;
Yun-chuan WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adrenergic alpha-Antagonists; pharmacology; Antineoplastic Agents; pharmacology; Cell Cycle; drug effects; Cell Line, Tumor; Cell Survival; drug effects; Dose-Response Relationship, Drug; Humans; Male; Phenoxybenzamine; pharmacology; Prazosin; administration & dosage; analogs & derivatives; pharmacology; Prostatic Neoplasms; pathology; Quinazolines; pharmacology
- From: Chinese Journal of Surgery 2004;42(10):604-606
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThe aim of the present study is to compare the effects of two alpha1-adrenoceptor antagonist terazosin and alfuzosin together with one alpha-adrenoceptor antagonist phenoxybenzamine on androgen-independent prostate cancer cell lines PC-3 and DU145.
METHODSTwo androgen- independent cell lines, PC-3 and DU145, were used to determine the cell viability, colony-forming ability as well as cell cycle characteristics after exposure to these three drugs.
RESULTSThis study showed that terazosin inhibited not only prostate cancer cell growth but also colony-forming ability, which is the main target of clinical treatment. On the other hand, alfuzosin and phenoxybenzamine have no effect on cell viability and colony forming ability of PC-3 and DU145. In addition, the terazosin inhibits cell growth through G(1) phase cell cycle arrest.
CONCLUSIONThis study provided the evidence that alpha1-adrenoceptor antagonist terazosin may have a therapeutic potential in the treatment of advanced androgen-independent prostate cancer.
