New exploration on effect of characteristics of traditional Chinese medicine components structure on multi-ingredient/component pharmacokinetics.
- Author:
Jun-Fei GU
;
Liang FENG
;
Ming-Hua ZHANG
;
Dong QIN
;
Xiao-Bin JIA
- Publication Type:Journal Article
- MeSH:
Animals;
Area Under Curve;
Chemistry, Pharmaceutical;
Humans;
Medicine, Chinese Traditional;
methods;
Pharmacokinetics;
Structure-Activity Relationship
- From:
China Journal of Chinese Materia Medica
2014;39(14):2782-2786
- CountryChina
- Language:Chinese
-
Abstract:
The study on the pharmacokinetics of traditional Chinese medicines (TCMs) is a linking science during the modernization of TCMs, and plays an important role in the studies on the complex material base of TCMs, the in vivo process of ingredient/ component and the pharmacokinetics-pharmacodynamics correlation. However, because of the multi-ingredient/component system of TCMs, how to scientifically reveal the pharmacokinetics that is consistent with TCMs' characteristics has long been a hotspot and difficulty for the exploration. The optimal composition structure of the material basis of TCMs shows the best efficacy, while the difference between the multi-ingredient/component composition structures in the efficacy is closely related to their absorption, transport, metabolism and excretion in vivo. In this article, the authors systematically review the study methods for pharmacokinetics of TCMs and their compounds, and explore the pharmacokinetics of TCMs based on the "component structure theory". As a result, the method for integrating TCM component structure and the TCM pharmacokinetics was proposed to be adopted to intensively study the effect of the component structure on the in vivo TCM multi-ingredient/component pharmacokinetic characteristics, in order to promote the TCM modernization and innovation in China.
