Application of CADD on multi-target drug R&D in natural products.
- Author:
Lian-Sheng QIAO
;
Yan-Ling ZHANG
- Publication Type:Journal Article
- MeSH:
Biological Products;
chemical synthesis;
pharmacology;
Biomedical Research;
instrumentation;
Computer-Aided Design;
Drug Design;
Humans;
Molecular Targeted Therapy
- From:
China Journal of Chinese Materia Medica
2014;39(11):1951-1955
- CountryChina
- Language:Chinese
-
Abstract:
Multi-target drugs can simultaneously adjust multiple links of the disease network. Despite the higher efficacy and lower toxicity caused by single targets, multi-target drugs become ideal drugs for treating complicated diseases as well the main direction of drug R & D. By virtue of their structural diversity, higher multi-target activity and lower toxicity, natural products become an important source for developing multi-target drugs. Computer-aided drug design (CADD) is a commonly used multi-target drug R&D method, which mainly includes virtual screening and pharmacophore design. In this paper, the authors made a systematical analysis and discussed the prospects and advantages of various methods for multi-target drug R&D with natural products.
